منابع مشابه
p21 expression predicts outcome in p53-null ovarian carcinoma.
PURPOSE p21 is a direct p53 response gene. Although several studies have correlated p21 and p53 expression, only one has evaluated p21 expression as a function of sequenced p53 gene mutation. We hypothesize that such an analysis may be useful in prognosticating outcome for individuals diagnosed with epithelial ovarian cancer. EXPERIMENTAL DESIGN DNA from the primary ovarian cancers of 267 pat...
متن کاملAssociation of p21, p21 p27 and p21 p53 status to histological subtypes and prognosis in low-stage epithelial ovarian cancer.
AIM The objective of this study was to evaluate the prognostic value of p21 alone and in combination with p53 or p27 for different histological subtypes of epithelial ovarian cancer and disease-free survival. PATIENTS AND METHODS The specimens were obtained at primary surgery from a series of 129 ovarian carcinomas in FIGO stages I-II. The technique of tissue microarray and immunohistochemist...
متن کامل[Incidence of proapoptotic proteins p53 and p21 in epithelial ovarian tumors].
OBJECTIVE The aim of the study was to evaluate the expression of proapoptotic proteins p53 and p21 in cystadenomas, borderline tumors and ovarian cancers. The correlation between proapoptotic proteins and selected parameters of ovarian tumors was also assessed. MATERIAL AND METHODS The study group consisted of 66 patients operated on because of epithelial ovarian tumor The study group was fur...
متن کاملThe gene expression level of p53 and p21 in mouse brain exposed to radiofrequency field
Background: Widespread and growing sources of electromagnetic radiation raised concerns attributed to the potential adverse health risk of radiofrequency fields. Given the functional importance of the hippocampus, this study aimed to investigate the effects of electromagnetic waves radiated by mobile jammer on hippocampal expression of p21 and p53 genes as regulators of cellular apoptosis...
متن کاملp53 in the diagnosis of human neoplasia.
The traditional methods used to diagnose cancer and predict its course have been increasingly aided by molecular genetics. Unique, molecular genetic tumor markers are a consequence of the clonal expansion of cells which harbor one or more altered genes. Converging lines of evidence now firmly document that cancer is a type of genetic disease with genomic changes that are often somatically acqui...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Gynecological Cancer
سال: 1997
ISSN: 1048-891X,1525-1438
DOI: 10.1046/j.1525-1438.1997.00457.x